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Chemical Structure : BMS-986142
CAS No.: 1643368-58-4
Catalog No.: PC-60422Not For Human Use, Lab Use Only.
BMS-986142 (BMS 986142) is a potent, selective and reversible BTK inhibitor with IC50 of 0.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BMS-986142 (BMS 986142) is a potent, selective and reversible BTK inhibitor with IC50 of 0.5 nM.
BMS-986142 displays 20-60-fold selectivity over Tec family kinases, >10,000-fold selectivity over JAK2.
BMS-986142 potently inhibits signaling and functional end points, including calcium flux (IC50=9 nM), production of cytokines, proliferation, and surface expression of CD86 (IC50=3-4 nM).
BMS-986142 potently inhibits BCR-stimulated expression of CD69 on B cells in human whole blood with IC50 of 90 nM.
BMS-986142 exhibits excellent in vivo properties and efficacy, and a very desirable tolerability and safety profile.
| M.Wt | 572.613 | |
| Formula | C32H30F2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide |
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1. Watterson SH, et al. J Med Chem. 2016 Oct 13;59(19):9173-9200.
2. Lee SK, et al. Eur J Clin Pharmacol. 2017 Jun;73(6):689-698.
3. Gillooly KM, et al. PLoS One. 2017 Jul 24;12(7):e0181782.
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