Catalog No.: PC-22117Not For Human Use, Lab Use Only.
BMS-986365 (CC-94676) is a highly potent and selective androgen receptor (AR) degrader with DC50 of 10-40 nM, induces rapid and deep degradation of both wildtype and mutant forms of AR.
BMS-986365 (CC-94676) is a highly potent and selective androgen receptor (AR) degrader with DC50 of 10-40 nM, induces rapid and deep degradation of both wildtype and mutant forms of AR.
BMS-986365 is a heterobifunctional ligand-directed degrader (LDD) that enables the CRL4CRBN E3 ligase-dependent ubiquitination and degradation of AR.
100-fold more potent than enzalutamide (ENZ) at inhibiting androgen-stimulated transcription of AR target genes, and 10 to 120-fold more potent than ENZ at inhibiting AR-dependent proliferation of multiple prostate cancer cell lines in vitro.
BMS-986365 demonstrates on-target activity, degrading AR, suppressing AR signaling, and inhibiting tumor growth in animal models of advanced prostate cancer, with tumor volume reductions of 63-92% in therapy resistant patient-derived xenografts, including those with acquired resistance to ENZ.
