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BMS 814580 phosphate

Chemical Structure : BMS 814580 phosphate

CAS No.: 1197420-12-4

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BMS 814580 phosphate (BMS814580;BMS-814580)

Catalog No.: PC-61119Not For Human Use, Lab Use Only.

A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM; exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM, dose-dependently reduces body weight in chronic diet-induced obese models with excellent safety profile.

Physicochemical Properties

M.Wt 584.912
Formula C24H20ClF2N2O7PS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one phosphate

References

1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858.

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