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Chemical Structure : BMY 45778
Catalog No.: PC-60722Not For Human Use, Lab Use Only.
BMY 45778 is a potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.
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BMY 45778 is a potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.
BMY 45778 activates adenylyl cyclase (ED50=6-10 nM) and stimulates GTPase in human platelet membrane preparations.
BMY 45778 prevents [3H]]Iloprost binding to platelet membranes with IC50 of 7 nM, causes elevation of platelet cAMP levels (cAMP content doubles at 13 nM) and activation of the cAMP-dependent protein kinase in whole platelets.
| M.Wt | 438.44 | |
| Formula | C26H18N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Meanwell NA, et al. J Med Chem. 1993 Nov 26;36(24):3884-903.
2. Seiler SM, et al. Prostaglandins. 1997 Jan;53(1):21-35.
3. Rudd JA, et al. Br J Pharmacol. 2000 Feb;129(4):782-90.
4. Chow KB, et al. Br J Pharmacol. 2001 Dec;134(7):1375-84.
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