Catalog No.: PC-60722Not For Human Use, Lab Use Only.
BMY 45778 is a potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.
BMY 45778 is a potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation.
BMY 45778 activates adenylyl cyclase (ED50=6-10 nM) and stimulates GTPase in human platelet membrane preparations.
BMY 45778 prevents [3H]]Iloprost binding to platelet membranes with IC50 of 7 nM, causes elevation of platelet cAMP levels (cAMP content doubles at 13 nM) and activation of the cAMP-dependent protein kinase in whole platelets.
