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Chemical Structure : BNC210
Catalog No.: PC-21672Not For Human Use, Lab Use Only.
BNC210 (BNC 210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively.
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BNC210 (BNC 210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively.
BNC210 inhibits acetylcholine, nicotine, choline and PNU-282987.
BNC210 is not active at other members of the cys-loop ligand gated ion channel family when tested at 3 and 10 μM for selectivity against the α1β1δε, α3β4, α4β2 nAChRs and the 5HT3a and GABAA receptors in a Ca++ flux fluorescence-based functional assay.
BNC210 demonstrates anxiolytic-like behavior in rodent tests.
| M.Wt | 418.50 | |
| Formula | C24H26N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. O'Connor SM, et al. Neuropharmacology. 2024 Jan 5:109836.
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