Chemical Structure : BNC210
CAS No.:
1020634-41-6
BNC210
(BNC 210)
Catalog No.: PC-21672Not For Human Use, Lab Use Only.
BNC210 (BNC 210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BNC210 (BNC 210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively.
BNC210 inhibits acetylcholine, nicotine, choline and PNU-282987.
BNC210 is not active at other members of the cys-loop ligand gated ion channel family when tested at 3 and 10 μM for selectivity against the α1β1δε, α3β4, α4β2 nAChRs and the 5HT3a and GABAA receptors in a Ca++ flux fluorescence-based functional assay.
BNC210 demonstrates anxiolytic-like behavior in rodent tests.
Physicochemical Properties
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M.Wt
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418.50
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Formula
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C24H26N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-[(2,3-dihydro-1H-inden-2-yl)amino]-1-ethyl-3-(4-morpholinylcarbonyl)-1,8-naphthyridin-4(1H)-one
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References
1. O'Connor SM, et al. Neuropharmacology. 2024 Jan 5:109836.
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