Catalog No.: PC-21672Not For Human Use, Lab Use Only.
Soclenicant (BNC210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively.
Soclenicant (BNC210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively.
BNC210 inhibits acetylcholine, nicotine, choline and PNU-282987.
BNC210 is not active at other members of the cys-loop ligand gated ion channel family when tested at 3 and 10 μM for selectivity against the α1β1δε, α3β4, α4β2 nAChRs and the 5HT3a and GABAA receptors in a Ca++ flux fluorescence-based functional assay.
BNC210 demonstrates anxiolytic-like behavior in rodent tests.
