Chemical Structure : BPR2-D2
CAS No.:
86882-62-4
BPR2-D2
Catalog No.: PC-24923Not For Human Use, Lab Use Only.
BPR2-D2 is a small molecule inhibitor against influenza virus with excellent antiviral efficacy for the oseltamivir-resistant virus (EC50= 0.021 to 0.040 uM), may target viral ribonucleoproteins (RNPs) for viral RNA synthesis, also inhibits SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) with IC50 of 4.6 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BPR2-D2 is a small molecule inhibitor against influenza virus with excellent antiviral efficacy for the oseltamivir-resistant virus (EC50= 0.021 to 0.040 uM), may target viral ribonucleoproteins (RNPs) for viral RNA synthesis, also inhibits SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) with IC50 of 4.6 uM.
BPR2-D2 inhibits 100% of the virus-induced CPE at a concentration of 0.05 µM.
BPR2-D2 also exhibits a broad antiviral spectrum against various strains of influenza A and influenza B viruses.
BPR2-D2 has previously shown notable anti-influenza activity and broad-spectrum inhibitory effects against RNA viruses.
BPR2-D2 effectively inhibits SARS-CoV-2 by modulating its RdRp function.
Physicochemical Properties
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M.Wt
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380.40
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Formula
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C25H16O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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8-benzoyl-4-methyl-9-phenyl-2H-furo[2,3-h]chromen-2-one
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References
1. Shih SR, et al. J Antimicrob Chemother. 2010 Jan;65(1):63-71.
2. Tang WF, et al. Biomed Pharmacother. 2025 Jun 20;189:118252.
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