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Chemical Structure : BPR3P0128
Catalog No.: PC-22716Not For Human Use, Lab Use Only.
BPR3P0128 is a potent, non-nucleoside viral RNA-dependent RNA polymerase (RdRp) inhibitor with EC05 of 0.66 uM, inhibits influenza viral replication with IC50 of 51-190 nM in MDCK cells, inhibits SARS-CoV-2 variants of concern.
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BPR3P0128 is a potent, non-nucleoside viral RNA-dependent RNA polymerase (RdRp) inhibitor with EC05 of 0.66 uM, inhibits influenza viral replication with IC50 of 51-190 nM in MDCK cells, inhibits SARS-CoV-2 variants of concern.
BPR3P0128 demonstrated broad-spectrum activity against various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.
BPR3P0128 does not affect the early entry stage, as evidenced by a time-of-drug-addition assay.
BPR3P0128 effectively reduced the expression of proinflammatory cytokines in human lung epithelial Calu-3 cells infected with SARS-CoV-2.
A combination of BPR3P0128 and remdesivir had a synergistic effect-a result likely due to both drugs interacting with separate domains of the RdRp.
| M.Wt | 436.31 | |
| Formula | C22H18BrN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tang W-F, et al. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0095623.
2. Hsu JT, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):647-57.
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