Chemical Structure : BPR3P0128
CAS No.:
1345406-09-8
BPR3P0128
Catalog No.: PC-22716Not For Human Use, Lab Use Only.
BPR3P0128 is a potent, non-nucleoside viral RNA-dependent RNA polymerase (RdRp) inhibitor with EC05 of 0.66 uM, inhibits influenza viral replication with IC50 of 51-190 nM in MDCK cells, inhibits SARS-CoV-2 variants of concern.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BPR3P0128 is a potent, non-nucleoside viral RNA-dependent RNA polymerase (RdRp) inhibitor with EC05 of 0.66 uM, inhibits influenza viral replication with IC50 of 51-190 nM in MDCK cells, inhibits SARS-CoV-2 variants of concern.
BPR3P0128 demonstrated broad-spectrum activity against various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.
BPR3P0128 does not affect the early entry stage, as evidenced by a time-of-drug-addition assay.
BPR3P0128 effectively reduced the expression of proinflammatory cytokines in human lung epithelial Calu-3 cells infected with SARS-CoV-2.
A combination of BPR3P0128 and remdesivir had a synergistic effect-a result likely due to both drugs interacting with separate domains of the RdRp.
Physicochemical Properties
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M.Wt
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436.31
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Formula
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C22H18BrN3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-Bromo-2-[1-(2,5-dimethylphenyl)-5-methyl-1H-pyrazol-4-yl]-4-quinolinecarboxylic acid
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References
1. Tang W-F, et al. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0095623.
2. Hsu JT, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):647-57.
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