Catalog No.: PC-43147Not For Human Use, Lab Use Only.
BPTES is a potent, selective kidney-type glutaminase 1 (GLS1) inhibitor with Ki of 3 uM (rat KGA), selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase.
BPTES is a potent, selective kidney-type glutaminase 1 (GLS1) inhibitor with Ki of 3 uM (rat KGA), selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase.
BPTES inhibits the allosteric activation caused by phosphate binding and promotes the formation of an inactive complex.
BPTES slows growth of glioblastoma cells expressing mutant IDH1 compared with those expressing wild-type IDH1, lowers glutamate and α-KG levels, and increases glycolytic intermediates while leaving total 2-HG levels unaffected.
BPTES nanoparticles significantly reduces pancreatic tumor combined with metformin in vivo.
