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Chemical Structure : BRK inhibitor P21d
Catalog No.: PC-35189Not For Human Use, Lab Use Only.
BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM).
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BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM); exhibits potent cellular activity with p-SAM68 IC50 of 52 nM, downregulates SNAIL protein and restores E-cadherin expression in TNBC cells; suppresses migration of MDA-MB-231 and MMTV-myc cells, sensitizes TNBC cells to anoikis and suppresses metastasis formation.
| M.Wt | 447.474 | |
| Formula | C23H22FN7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zeng H, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5870-5.
2. Ito K, et al. Cancer Res. 2016 Aug 1;76(15):4406-17.
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