Catalog No.: PC-38384Not For Human Use, Lab Use Only.
Baxdrostat (CIN-107, RO6836191) is a highly potent, selective, and competitive small molecule inhibitor of aldosterone synthase (CYP11 B2, steroid 18-hydroxylase) with Ki of 13 nM, >100-fold over 11β-hydroxylase.
Baxdrostat (CIN-107, RO6836191) is a highly potent, selective, and competitive small molecule inhibitor of aldosterone synthase (CYP11 B2, steroid 18-hydroxylase) with Ki of 13 nM, >100-fold over 11β-hydroxylase.
Baxdrostat (CIN-107, RO6836191) inhibited aldosterone synthesis without affecting the adrenocorticotropic hormone–induced rise in cortisol.
Baxdrostat (CIN-107, RO6836191) suppresses aldosterone production completely in humans without affecting cortisol production.
1. Bogman K, Schwab D, Delporte ML, Palermo G, Amrein K, Mohr S, et al. Preclinical and early clinical profile of a highly selective and potent oral inhibitor of aldosterone synthase (CYP11B2). Hypertension. 2017;69:189–96.
