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Chemical Structure : CC-401 hydrochloride
CAS No.: 1438391-30-0
Catalog No.: PC-43332Not For Human Use, Lab Use Only.
CC-401 hydrochloride is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases, including p38, ERK, IKK2, PK C, Lck, and ZAP70.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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CC-401 hydrochloride is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50 nM, displays >40-fold selectivity over other related kinases, including p38, ERK, IKK2, PK C, Lck, and ZAP70.
CC-401 decreases hepatic necrosis and apoptosis after orthotopic liver transplantation in vivo.
CC-401 blocks JNK signaling in the rat obstructed kidney and significantly inhibits renal fibrosis in terms of interstitial myofibroblast accumulation and collagen IV deposition.
CC-401 also significantly reduces tubular apoptosis in the obstructed kidney.
CC-401 sensitizes hypoxic colon cancer cells to DNA-damaging agents, potentiates the effect of bevacizumab and oxaliplatin in HT29-derived mouse xenografts.
| M.Wt | 424.9265 | |
| Formula | C22H25ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO (42.4 mg/mL) |
|
| Chemical Name/SMILES |
1H-Indazole, 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-, hydrochloride (1:1) |
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1. Uehara T, et al. Transplantation. 2004 Aug 15;78(3):324-32.
2. Uehara T, et al. J Hepatol. 2005 Jun;42(6):850-9.
3. Ma FY, et al. J Am Soc Nephrol. 2007 Feb;18(2):472-84.
4. Vasilevskaya IA, et al. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.
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