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CGP 37157

Chemical Structure : CGP 37157

CAS No.: 75450-34-9

CGP 37157 (CGP37157, CGP-37157)

Catalog No.: PC-61112Not For Human Use, Lab Use Only.

CGP37157 is a specific inhibitor of mitochondrial Na(+)-Ca(2+) exchanger (mNCE) with IC50 of 1.5 uM in INS-1 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CGP37157 is a specific inhibitor of mitochondrial Na(+)-Ca(2+) exchanger (mNCE) with IC50 of 1.5 uM in INS-1 cells.
CGP37157 decreases the amplitude of the mitochondrion-mediated plateau phase in cultured rat dorsal root ganglion neurons with IC50 of 4 uM.
CGP37157 increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets.

Physicochemical Properties

M.Wt 324.22
Formula C15H11Cl2NOS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

References

1. Baron KT, et al. Eur J Pharmacol. 1997 Dec 11;340(2-3):295-300.

2. Lee B, et al. Diabetes. 2003 Apr;52(4):965-73.

3. Montero M, et al. Mol Biol Cell. 2001 Jan;12(1):63-71.

4. Visch HJ, et al. J Biol Chem. 2004 Sep 24;279(39):40328-36.

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