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Chemical Structure : CGS-15943
CAS No.: 104615-18-1
Catalog No.: PC-38488Not For Human Use, Lab Use Only.
CGS-15943 is a potent, non-xanthine adenosine receptor antagonist with Ki values of 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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CGS-15943 is a potent, non-xanthine adenosine receptor antagonist with Ki values of 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively.
CGS 15943 also inhibits the kinase activity of the class IB PI3K isoform p110γ with an IC50 of 1.1 μM and shows slight inhibition on p110δ with an IC50 of 8.47 μM.
CGS 15943 inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells.
CGS 15943 reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in SK-Hep-1 cells.
| M.Wt | 285.69 | |
| Formula | C13H8ClN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine |
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1. Williams M, et al. J Pharmacol Exp Ther. 1987 May;241(2):415-20.
2. Ghai G, et al. J Pharmacol Exp Ther. 1987 Sep;242(3):784-90.
3. Francis JE, et al. J Med Chem. 1988 May;31(5):1014-20.
4. Edling CE, et al. Cancer Biol Ther. 2014 May;15(5):524-32.
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