You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Aryl hydrocarbon Receptor (AhR)-CH-223191
CH-223191

Chemical Structure : CH-223191

CAS No.: 301326-22-7

CH-223191 (CH223191)

Catalog No.: PC-43148Not For Human Use, Lab Use Only.

CH-223191 is a potent, specific antagonist of AhR (aryl hydrocarbon receptor), potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM.

Packing Price Stock Quantity
10 mg $98 In stock
25 mg $158 In stock
50 mg $258 In stock
100 mg $428 In stock
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CH-223191 (CH223191) is a potent, specific antagonist of AhR (aryl hydrocarbon receptor), potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM.
CH-223191 shows more inhibitory potency and no agonist-like effect, compared with flavone, resveratrol, and α-naphthoflavone, as well as estrogenic potency.
CH-223191 inhibits TCDD-AhR binding and TCDD-induced nuclear translocation and DNA binding of AhR, prevents the expression of cytochrome P450 enzymes, target genes of the AhR.
CH-223191 potently prevents TCDD-elicited cytochrome P450 induction, liver toxicity, and wasting syndrome in mice

Physicochemical Properties

M.Wt 333.3871
Formula C19H19N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 35 mg/mL

Chemical Name/SMILES

1H-Pyrazole-5-carboxamide, 1-methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-

References

1. Kim SH, et al. Mol Pharmacol. 2006 Jun;69(6):1871-8.

2. Veldhoen M, et al. J Exp Med. 2009 Jan 16;206(1):43-9.

3. Gramatzki D, et al. Oncogene. 2009 Jul 16;28(28):2593-605.

4. Shackleford G, et al. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1319-E1328.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: