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Chemical Structure : CHD1L inhibitor 6
Catalog No.: PC-38167Not For Human Use, Lab Use Only.
CHD1L inhibitor 6 is the first-in-class small molecule inhibitor of oncogenic CHD1L with IC50 of 5.5 uM in cat-CHD1L ATPase assay.
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CHD1L inhibitor 6 is the first-in-class small molecule inhibitor of oncogenic CHD1L with IC50 of 5.5 uM in cat-CHD1L ATPase assay.
CHD1L effectively downregulated vimentin promoter activity with EC50 of 4.7 uM against CHD1L mediated TCF- transcription, reverse EMT and the malignant phenotype in CRC.
CHD1L inhibitor 6 is effective against patient-derived tumor organoids (PDTOs) with EC50 of 11.6 uM.
CHD1L inhibitor 6 displays good PK drug-like properties and the ability to alter EMT and induce apoptosis in vivo with no observed liver toxicity.
| M.Wt | 393.509 | |
| Formula | C21H23N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Joshua M Abbott, et al. Mol Cancer Ther. 2020 Aug;19(8):1598-1612.
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