CHD1L inhibitor 6 |CAS:1251562-51-2 Probechem Biochemicals

Chemical Structure : CHD1L inhibitor 6

CHD1L inhibitor 6

Catalog No.: PC-38167Not For Human Use, Lab Use Only.

CHD1L inhibitor 6 is the first-in-class small molecule inhibitor of oncogenic CHD1L with IC50 of 5.5 uM in cat-CHD1L ATPase assay.

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Biological Activity

CHD1L inhibitor 6 is the first-in-class small molecule inhibitor of oncogenic CHD1L with IC50 of 5.5 uM in cat-CHD1L ATPase assay.
CHD1L effectively downregulated vimentin promoter activity with EC50 of 4.7 uM against CHD1L mediated TCF- transcription, reverse EMT and the malignant phenotype in CRC.
CHD1L inhibitor 6 is effective against patient-derived tumor organoids (PDTOs) with EC50 of 11.6 uM.
CHD1L inhibitor 6 displays good PK drug-like properties and the ability to alter EMT and induce apoptosis in vivo with no observed liver toxicity.

Physicochemical Properties

M.Wt	393.509
Formula	C21H23N5OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)-2-(thiophen-2-yl)acetamide

References

1. Joshua M Abbott, et al. Mol Cancer Ther. 2020 Aug;19(8):1598-1612.