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CHD1L inhibitor 6

Chemical Structure : CHD1L inhibitor 6

CAS No.: 1251562-51-2

CHD1L inhibitor 6

Catalog No.: PC-38167Not For Human Use, Lab Use Only.

CHD1L inhibitor 6 is the first-in-class small molecule inhibitor of oncogenic CHD1L with IC50 of 5.5 uM in cat-CHD1L ATPase assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CHD1L inhibitor 6 is the first-in-class small molecule inhibitor of oncogenic CHD1L with IC50 of 5.5 uM in cat-CHD1L ATPase assay.
    CHD1L effectively downregulated vimentin promoter activity with EC50 of 4.7 uM against CHD1L mediated TCF- transcription, reverse EMT and the malignant phenotype in CRC.
    CHD1L inhibitor 6 is effective against patient-derived tumor organoids (PDTOs) with EC50 of 11.6 uM.
    CHD1L inhibitor 6 displays good PK drug-like properties and the ability to alter EMT and induce apoptosis in vivo with no observed liver toxicity.

    Physicochemical Properties

    M.Wt 393.509
    Formula C21H23N5OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(4-((6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)-2-(thiophen-2-yl)acetamide

    References

    1. Joshua M Abbott, et al. Mol Cancer Ther. 2020 Aug;19(8):1598-1612.

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