Chemical Structure : CHI-KAT8i5
CAS No.:
2839860-29-4
CHI-KAT8i5
Catalog No.: PC-23724Not For Human Use, Lab Use Only.
CHI-KAT8i5 is a specific small molecule inhibitor of KAT8 (lysine acetyltransferase 8), directly binds to KAT8 with SPR KD of 19.72 uM, suppresses esophageal squamous cell carcinoma (ESCC) growth through targeting KAT8/c-Myc signaling pathway.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CHI-KAT8i5 is a specific small molecule inhibitor of KAT8 (lysine acetyltransferase 8), directly binds to KAT8 with SPR KD of 19.72 uM, suppresses esophageal squamous cell carcinoma (ESCC) growth through targeting KAT8/c-Myc signaling pathway.
CHI-KAT8i5 suppresses ESCC cell proliferation (IC50=2-3 uM) through the inhibition of KAT8 lysine acetyltransferase activity.
CHI-KAT8i5 does not bind to other proteins in HAT family (KAT2A, KAT2B, KAT5, and KAT7).
CHI-KAT8i5 could significantly inhibit KYSE 30 and KYSE 150 clone formation, 5 and 15 μM CHI-KAT8i5 induces cancer cell apoptosis in a dose-dependent manner.
CHI-KAT8i5 (2-15 uM) dose-dependently decreases H4K16ace and c-Myc in KYSE30 cells, suppresses NPM1 and PPAT transcript expression in ESCC cell lines.
CHI-KAT8i5 (50 or 200 mg/kg) suppresses ESCC tumor growth in patient-derived ESCC xenografts.
Physicochemical Properties
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M.Wt
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523.68
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Formula
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C23H29N3O5S3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4-(N,N-diethylsulfamoyl)-3-hydroxystyryl)-N,N-diethylbenzo[d]thiazole-6-sulfonamide
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References
1. Zhang D, et al. Cell Rep. 2025 Jan 7;44(1):115135.
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