Catalog No.: PC-24328Not For Human Use, Lab Use Only.
CHMFL-FLT3-122 is a potent, selective and orally active FLT3 kinase with IC50 of 40 nM, shows >10-fold selectivity over BTK (IC50=421 nM) and c-KIT (IC50=559 nM) kinases.
CHMFL-FLT3-122 is a potent, selective and orally active FLT3 kinase with IC50 of 40 nM, shows >10-fold selectivity over BTK (IC50=421 nM) and c-KIT (IC50=559 nM) kinases.
CHMFL-FLT3-122 demonstrates 170-fold selectivity between FLT3 kinase and c-KIT kinase (GI50 = 11 nM versus 1900 nM) in the TEL-fusion isogenic BaF3 cells.
CHMFL-FLT3-122 induces apoptosis by arresting the cell cycle into the G0/G1 phase.
CHMFL-FLT3-122 significantly inhibits the proliferation of FLT3-ITD positive AML cancer cell lines MV4-11 (GI50 = 22 nM), MOLM13/14 (GI50 = 21 nM/42 nM).
CHMFL-FLT3-122 demonstrates a good bioavailability (30%) and significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft model (50 mg/kg) without exhibiting obvious toxicity.
