Catalog No.: PC-49321Not For Human Use, Lab Use Only.
CHR-6494 (CHR6494) is a potent, selective inhibitor of the histone kinase Haspin with IC50 of 2 nM, shows anti-proliferative effects in human cancer cells.
CHR-6494 (CHR6494) is a potent, selective inhibitor of the histone kinase Haspin with IC50 of 2 nM, shows anti-proliferative effects in human cancer cells.
CHR-6494 displays selectivity over 27 other protein kinases including Aurora B kinase.
CHR-6494 inhibits cancer cell growth dose dependently with IC50 500 nM for HCT-116, 473 nM for HeLa and 752 nM for MDA-MB-231 cells.
CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification.
CHR-6494 causes arrest in G2/M and subsequently apoptosis in cancer cells.
CHR-6494 demonstrates anti-angiogenetic features in ex vivo assays, shows antitumor potential in xenografted nude mice without any observed toxicity in vivo.
