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Chemical Structure : CJ-042794
CAS No.: 847728-01-2
Catalog No.: PC-42700Not For Human Use, Lab Use Only.
CJ-042794 (CJ-42794) is a potent, selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $188 | In stock | |
| 100 mg | $318 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CJ-042794 (CJ-42794) is a potent, selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5.
CJ-042794 displays >200-fold more selective for human EP4 receptor than EP1, EP2, and EP3.
CJ-042794 competitively inhibits PGE2-evoked elevations of intracellular cAMP levels in HEK293 cells overexpressing EP4 receptor with a mean pA(2) value of 8.6.
CJ-042794 reverses the inhibitory effects of PGE2 on LPS-induced TNFα production.
| M.Wt | 413.8261 | |
| Formula | C22H17ClFNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]- |
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1. Takeuchi K, et al. J Pharmacol Exp Ther. 2007 Sep;322(3):903-12.
2. Murase A, et al. Life Sci. 2008 Jan 16;82(3-4):226-32.
3. Murase A, et al. Eur J Pharmacol. 2008 Feb 2;580(1-2):116-21.
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