CJ-042794 |CAS:847728-01-2 Probechem Biochemicals

Chemical Structure : CJ-042794

CAS No.: 847728-01-2

CJ-042794 (CJ-42794;CJ42794;CJ 042794)

Catalog No.: PC-42700Not For Human Use, Lab Use Only.

CJ-042794 (CJ-42794) is a potent, selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5.

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Biological Activity

CJ-042794 (CJ-42794) is a potent, selective prostaglandin E receptor subtype 4 (EP4) antagonist with pKi of 8.5.
CJ-042794 displays >200-fold more selective for human EP4 receptor than EP1, EP2, and EP3.
CJ-042794 competitively inhibits PGE2-evoked elevations of intracellular cAMP levels in HEK293 cells overexpressing EP4 receptor with a mean pA(2) value of 8.6.
CJ-042794 reverses the inhibitory effects of PGE2 on LPS-induced TNFα production.

Physicochemical Properties

M.Wt	413.8261
Formula	C22H17ClFNO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	Benzoic acid, 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-

References

1. Takeuchi K, et al. J Pharmacol Exp Ther. 2007 Sep;322(3):903-12.

2. Murase A, et al. Life Sci. 2008 Jan 16;82(3-4):226-32.

3. Murase A, et al. Eur J Pharmacol. 2008 Feb 2;580(1-2):116-21.

CJ-042794 (CJ-42794;CJ42794;CJ 042794)

Biological Activity

Physicochemical Properties

References

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