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Chemical Structure : CKR-49-17
Catalog No.: PC-21547Not For Human Use, Lab Use Only.
CKR-49-17 is a potent, allosteric small molecule activator of CK1γ2 with Kd value of 180 nM in MST assays.
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CKR-49-17 is a potent, allosteric small molecule activator of CK1γ2 with Kd value of 180 nM in MST assays.
CKR-49-17 increases phosphorylation of Presenilin 1 (PS1)-pS367 in vitro with IC50 of 60 uM.
CKR-49-17 shows binding affinity for CK1γ2 D128A mutant with SPR Kd of 750 nM.
CKR-49-17 decreased C99 levels with IC50 of 15 uM in N2A cells stably overexpressing APP-695, decreased the levels of Aβ40 and Aβ42.
| M.Wt | 391.49 | |
| Formula | C21H21N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bustos VH, et al. ACS Chem Biol. 2023 Dec 11. doi: 10.1021/acschembio.3c00425.
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