CKR-49-17

Chemical Structure : CKR-49-17

Catalog No.: PC-21547Not For Human Use, Lab Use Only.

CKR-49-17 is a potent, allosteric small molecule activator of CK1γ2 with Kd value of 180 nM in MST assays.

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Biological Activity

CKR-49-17 is a potent, allosteric small molecule activator of CK1γ2 with Kd value of 180 nM in MST assays.
CKR-49-17 increases phosphorylation of Presenilin 1 (PS1)-pS367 in vitro with IC50 of 60 uM.
CKR-49-17 shows binding affinity for CK1γ2 D128A mutant with SPR Kd of 750 nM.
CKR-49-17 decreased C99 levels with IC50 of 15 uM in N2A cells stably overexpressing APP-695, decreased the levels of Aβ40 and Aβ42.

Physicochemical Properties

M.Wt	391.49
Formula	C21H21N5OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-cyanobenzo[d]thiazol-2-yl)-4-((piperidin-4-ylamino)methyl)benzamide

References

1. Bustos VH, et al. ACS Chem Biol. 2023 Dec 11. doi: 10.1021/acschembio.3c00425.

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CKR-49-17

Biological Activity

Physicochemical Properties

References

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