Catalog No.: PC-25787Not For Human Use, Lab Use Only.
CP105696 (CP-105696) is a highly potent, selective leukotriene B4 (LTB4) receptor 1 (BLT1) antagonist, inhibits binding of [3H]LTB4 to whole human neutrophils with IC50 of 5.6 nM, inhibits LTB4 induced chemotaxis of human neutrophils with IC50 of 5.2 nM.
CP105696 (CP-105696) is a highly potent, selective leukotriene B4 (LTB4) receptor 1 (BLT1) antagonist, inhibits binding of [3H]LTB4 to whole human neutrophils with IC50 of 5.6 nM, inhibits LTB4 induced chemotaxis of human neutrophils with IC50 of 5.2 nM. CP105696 competitively inhibits LTB4-mediated CD11b upregulation on human neutrophil (pA2 = 8.0). CP105696 (10 uM) does not inhibit either human neutrophil chemotaxis or CD11b upregulation mediated through alternate (i.e., C5a, IL-8, PAF) G-protein coupled chemotactic factor receptors. CP105696 inhibits LTB4 (5 nM)-mediated Ca++ mobilization in isolated human monocytes with IC50 of 940 nM. CP-105696 blocked neutrophil and eosinophil infiltration in cavine dermis mediated by either LTB4 or arachidonic acid with ED50 values of 0.3 +/- 0.1 mg/kg.
