Chemical Structure : CT1113
CAS No.:
2523435-18-7
CT1113
(CT-1113)
Catalog No.: PC-22261Not For Human Use, Lab Use Only.
CT1113 is a potent, selective small molecule USP25/USP28 inhibitor with IC50 of 26.1 nM/3.9 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CT1113 is a potent, selective small molecule USP25/USP28 inhibitor with IC50 of 26.1 nM/3.9 nM, respectively.
CT1113 displays no activity against other deubiquitinases and SENP1 at 1 uM.
CT1113 strongly destabilize NOTCH1 and inhibit the growth of T-ALL cells.
Inhibition of USP28 by CT1113 resulted in increased ubiquitination of the ICN1 protein in T-ALL cell lines (Jurkat and MOLT-4).
CT1113 induces apoptosis in T-ALL cells with or without mutant NOTCH1.
CT1113 significantly inhibited leukaemia progression in Jurkat xenograft, inhibits NOTCH1-driven T-cell leucaemogenesis.
CT1113 demonstrated anti-leukaemia efficacy in a NOTCH1-independent patient-derived T-ALL xenograft.
Physicochemical Properties
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M.Wt
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463.60
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Formula
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C25H29N5O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-[(3R)-7-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methyl-3-(methylamino)thieno[2,3-b]pyridine-2-carboxamide
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References
1. Jin Peng, et al. Signal Transduct Target Ther. 2022 Dec 8;7(1):393.
2. Jieyu Xu, et al. Br J Haematol. 2024 Apr 29. doi: 10.1111/bjh.19492.
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