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Chemical Structure : CT1113
Catalog No.: PC-22261Not For Human Use, Lab Use Only.
CT1113 is a potent, selective small molecule USP25/USP28 inhibitor with IC50 of 26.1 nM/3.9 nM, respectively.
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CT1113 is a potent, selective small molecule USP25/USP28 inhibitor with IC50 of 26.1 nM/3.9 nM, respectively.
CT1113 displays no activity against other deubiquitinases and SENP1 at 1 uM.
CT1113 strongly destabilize NOTCH1 and inhibit the growth of T-ALL cells.
Inhibition of USP28 by CT1113 resulted in increased ubiquitination of the ICN1 protein in T-ALL cell lines (Jurkat and MOLT-4).
CT1113 induces apoptosis in T-ALL cells with or without mutant NOTCH1.
CT1113 significantly inhibited leukaemia progression in Jurkat xenograft, inhibits NOTCH1-driven T-cell leucaemogenesis.
CT1113 demonstrated anti-leukaemia efficacy in a NOTCH1-independent patient-derived T-ALL xenograft.
| M.Wt | 463.60 | |
| Formula | C25H29N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jin Peng, et al. Signal Transduct Target Ther. 2022 Dec 8;7(1):393.
2. Jieyu Xu, et al. Br J Haematol. 2024 Apr 29. doi: 10.1111/bjh.19492.
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