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Chemical Structure : CVN417
Catalog No.: PC-21112Not For Human Use, Lab Use Only.
CVN417 (CVN-417) is a potent, selective and brain-penetrant α6-containing nicotinic acetylcholine receptor (α6 nAChR) antagonist with Ca2+ flux IC50 of 86 nM.
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CVN417 (CVN-417) is a potent, selective and brain-penetrant α6-containing nicotinic acetylcholine receptor (α6 nAChR) antagonist with Ca2+ flux IC50 of 86 nM.
CVN417 showed excellent selectivity over the nAChRα7 isoform (IC50>10 uM), weakly inhibits nAChRα3 and nAChRα4 isoforms (IC50, 2560 and 657 nM, respectively).
CVN417 blocks α6-containing nAChR activity in recombinant cells and reduces firing frequency of noradrenergic neurons in the rodent locus coeruleus.
CVN417 modulates phasic dopaminergic neurotransmission in an impulse-dependent manner.
CVN417 attenuates the behavioral phenotype in rodent model of resting tremor.
| M.Wt | 362.86 | |
| Formula | C18H23ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Louisa A Christie, et al. J Med Chem. 2023 Aug 31. doi: 10.1021/acs.jmedchem.3c00630.
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