Catalog No.: PC-21112Not For Human Use, Lab Use Only.
CVN417 (CVN-417) is a potent, selective and brain-penetrant α6-containing nicotinic acetylcholine receptor (α6 nAChR) antagonist with Ca2+ flux IC50 of 86 nM.
CVN417 (CVN-417) is a potent, selective and brain-penetrant α6-containing nicotinic acetylcholine receptor (α6 nAChR) antagonist with Ca2+ flux IC50 of 86 nM.
CVN417 showed excellent selectivity over the nAChRα7 isoform (IC50>10 uM), weakly inhibits nAChRα3 and nAChRα4 isoforms (IC50, 2560 and 657 nM, respectively).
CVN417 blocks α6-containing nAChR activity in recombinant cells and reduces firing frequency of noradrenergic neurons in the rodent locus coeruleus.
CVN417 modulates phasic dopaminergic neurotransmission in an impulse-dependent manner.
CVN417 attenuates the behavioral phenotype in rodent model of resting tremor.
