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Chemical Structure : Cercosporamide
Catalog No.: PC-45112Not For Human Use, Lab Use Only.
Cercosporamide is a broad-spectrum natural antifungal compound that acts as a selective and highly potent fungal Pkc1 kinase inhibitor, also inhibits Mnk inhibitor with IC50 of 116 nM and 11 nM for Mnk1 and Mnk2, respectively.
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Cercosporamide is a broad-spectrum natural antifungal compound that acts as a selective and highly potent fungal Pkc1 kinase inhibitor.
Cercosporamide potently and ATP-competitively inhibits C. albicans Pkc (CaPkc1) kinase with IC50 of <40 nM, Ki of 7 nM.
Cercosporamide shows potent antifungal activity with MIC of 10 ug/ml against both C. albicans and A. fumigatus.
Cercosporamide also is a potent, selective, orally bioavailable Mnk inhibitor with IC50 of 116 nM and 11 nM for Mnk1 and Mnk2, respectively.
Cercosporamide blocks eIF4E phosphorylation in cancer cells, inducing apoptosis, suppressing proliferation, and reducing soft agar colonization.
Cercosporamide is active in tumor xenograft model.
| M.Wt | 331.2769 | |
| Formula | C16H13NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sussman A, et al. Eukaryot Cell. 2004 Aug;3(4):932-43.
2. Konicek BW, et al. Cancer Res. 2011 Mar 1;71(5):1849-57.
3. Altman JK, et al. Blood. 2013 May 2;121(18):3675-81.
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