Cilofexor | FXR agonist | Probechem Biochemicals

Chemical Structure : Cilofexor

CAS No.: 1418274-28-8

Catalog No.: PC-61368Not For Human Use, Lab Use Only.

Cilofexor (GS-9674, GS9674, PX-104) is a potent, specific, non-steroidal farnesoid X receptor (FXR) agonist with EC50 of 43 nM.

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Biological Activity

Cilofexor (GS-9674, GS9674, PX-104) is a potent, specific, non-steroidal farnesoid X receptor (FXR) agonist with EC50 of 43 nM.

Cilofexor (GS-9674) reduces liver fibrosis and ameliorates portal hypertension in rat NASH models.

Cilofexor (GS-9674) demonstrates anti‐inflammatory and antifibrotic effects and reduced portal pressure in preclinical models of liver fibrosis.

Cilofexor (GS-9674) dose-dependently induces FXR target genes shp, cyp7a1 and fgf15 in hepatic and ileal tissues

Cilofexor (GS-9674) decreases portal hypertension and reduced liver fibrosis in NASH rats.

M.Wt	586.85
Formula	C28H22Cl3N3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[3-[2-Chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]-4-pyridinecarboxylic acid

1. Gege C, et al. Curr Top Med Chem. 2014;14(19):2143-58.

2. Trauner M, et al. Hepatology. 2019 Sep;70(3):788-801.

3. Schwabl P, et al. Biomedicines. 2021 Jan 9;9(1):60.