Chemical Structure : D-578
CAS No.:
2454461-06-2
D-578
(D578)
Catalog No.: PC-21114Not For Human Use, Lab Use Only.
D-578 is a potent, orally active triple monoamine reuptake inhibitor with Ki values of 16.2. 16.2, 3.23 nM, and 29.6, 20.6, 6.10 nM for the rat brain and cloned human dopamine, serotonin and norepinephrine transporters, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
D-578 is a potent, orally active triple monoamine reuptake inhibitor with Ki values of 16.2. 16.2, 3.23 nM, and 29.6, 20.6, 6.10 nM for the rat brain and cloned human dopamine, serotonin and norepinephrine transporters, respectively.
D-578 has moderate affinity for 5HT2c (Ki = 73 nM) and very weak affinity for 5HT2b (Ki = 425 nM), does not display appreciable affinity for other brain targets.
D-578 (10 mg/kg) shows efficacy in normalizing traumatic stress-induced extinction-retention learning in a fear conditioning SPS animal PTSD model experiment.
D-578 is far more efficacious than paroxetine (Cat# PC-46649), an SSRI currently used for treatment of PTSD.
Physicochemical Properties
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M.Wt
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481.56
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Formula
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C26H25F2N3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,4R,5R)-5-(((2-aminobenzo[d]thiazol-6-yl)methyl)amino)-2-(bis(4-fluorophenyl)methyl)tetrahydro-2H-pyran-4-ol
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References
1. Aloke K Dutta, et al. Eur J Pharmacol. 2019 Nov 5;862:172632.
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