Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Diacylglycerol Lipase (DAGL)-DAGL inhibitor DO34
DAGL inhibitor DO34

Chemical Structure : DAGL inhibitor DO34

CAS No.: 1848233-58-8

DAGL inhibitor DO34 (DO34)

Catalog No.: PC-61837Not For Human Use, Lab Use Only.

DAGL inhibitor DO34 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM 3-8 nM, respectively.

Packing Price Stock Quantity
5 mg $138 In stock
10 mg $218 In stock
25 mg $368 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DAGL inhibitor DO34 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM 3-8 nM, respectively.
DO34 shows excellent selectivity for DAGLs with the only detectable serine hydrolase off-targets being ABHD6 and PLA2G7.
DO34 significantly decreases whole brain levels of 2-AG, anandamide, and arachidonic acid in the mouse LPS inflammatory pain model.

Physicochemical Properties

M.Wt 531.53
Formula C26H28F3N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

tert-butyl 3-benzyl-4-(4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carbonyl)piperazine-1-carboxylate

References

1. Ogasawara D, et al. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33.

2. Deng H, et al. J Med Chem. 2017 Jan 12;60(1):428-440.

3. Wilkerson JL, et al. J Pharmacol Exp Ther. 2017 Oct 2. pii: jpet.117.243808.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: