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Chemical Structure : DAGL inhibitor DO34
CAS No.: 1848233-58-8
Catalog No.: PC-61837Not For Human Use, Lab Use Only.
DAGL inhibitor DO34 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM 3-8 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DAGL inhibitor DO34 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM 3-8 nM, respectively.
DO34 shows excellent selectivity for DAGLs with the only detectable serine hydrolase off-targets being ABHD6 and PLA2G7.
DO34 significantly decreases whole brain levels of 2-AG, anandamide, and arachidonic acid in the mouse LPS inflammatory pain model.
| M.Wt | 531.53 | |
| Formula | C26H28F3N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
tert-butyl 3-benzyl-4-(4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carbonyl)piperazine-1-carboxylate |
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1. Ogasawara D, et al. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33.
2. Deng H, et al. J Med Chem. 2017 Jan 12;60(1):428-440.
3. Wilkerson JL, et al. J Pharmacol Exp Ther. 2017 Oct 2. pii: jpet.117.243808.
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