Catalog No.: PC-26742Not For Human Use, Lab Use Only.
DALTAC-1 (JYZ3032, Domain-ALTeration Chimera 1) is a specific AR-p300/CBP Domain-ALTeration Chimeras (DALTAC), targets the AR-p300 complex by repurposing their natural interfaces to block activation of the AR oncogenic enhanceosome, selectively suppresses the growth of AR-positive prostate cancer cells.
DALTAC-1 (JYZ3032, Domain-ALTeration Chimera 1) is a specific AR-p300/CBP Domain-ALTeration Chimera (DALTAC), targets the AR-p300 complex by repurposing their natural interfaces to block activation of the AR oncogenic enhanceosome, selectively suppresses the growth of AR-positive prostate cancer cells.
DALTAC-1 induces AR and p300 proteins into proximity to form a stable ternary complex.
DALTAC-1-induced proximity of AR and p300 proteins inhibits their oncogenic transcriptional output in AR-positive prostate cancer cells.
DALTAC-1 selectively reprograms the acetylome in AR-positive prostate cancer cells.
DALTAC-1 potently suppresses the growth of prostate cancer organoids, exhibits potent in vivo efficacy against prostate cancer.
DALTAC-1 effectively redirects AR-p300 interactions, inhibiting p300 binding to the AR-NTD while enhancing its interaction with the AR-LBD.
