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Chemical Structure : DD205-291
Catalog No.: PC-23276Not For Human Use, Lab Use Only.
DD205-291 is a potent, selective and orally bioavailable PROTAC-based hematopoietic progenitor kinase 1 (HPK1, MAP4K1) degrader with DC50 of 8.8 nM.
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DD205-291 is a potent, selective and orally bioavailable PROTAC-based hematopoietic progenitor kinase 1 (HPK1, MAP4K1) degrader with DC50 of 8.8 nM.
DD205-291 showed a dose-dependent inhibition of SLP-76 phosphorylation and an induction of IL-2 and IFN-γ. DD205-291 exhibited good efficacy and a favorable safety profile in the MC38 model.
DD205-291 (0.5 mg/kg) in combination with anti-PD1 resulted in significant suppression with a TGI value of 91.0%.
| M.Wt | 775.23 | |
| Formula | C38H38ClF3N10O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhimin Zhang, et al. J Med Chem. 2024 Oct 24. doi: 10.1021/acs.jmedchem.4c01906.
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