Chemical Structure : DYRK inhibitor FC-3
CAS No.:
2805339-74-4
DYRK inhibitor FC-3
Catalog No.: PC-27003Not For Human Use, Lab Use Only.
DYRK inhibitor FC-3 is a potent, selective, reversible, ATP-competitive inhibitor of Dual-specificity tyrosine-regulated kinases (DYRKs) with IC50 of 53 nM (DYRK1A).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DYRK inhibitor FC-3 is a potent, selective, reversible, ATP-competitive inhibitor of Dual-specificity tyrosine-regulated kinases (DYRKs) with IC50 of 53 nM (DYRK1A).
The gatekeeper mutants F238L and M240R demonstrated resistance to FC-2 with IC50 of 1-2.5 uM, F238L-M240R double mutant has IC50 of 4 uM.
FC-3 (5-20 uM) reduces neurosphere proliferation and cell invasion of GBM cell line U87MG by specifically targeting DYRK1A.
FC-3 enhances EGFR ubiquitination, leading to its lysosomal degradation in EGFR-dependent glioblastoma cell-based models.
FC-3 (2 mg/kg daily) attenuates DYRK1A-mediated tumorigenesis in U87MG subcutaneous xenograft model of Nu/J nude mice.
Physicochemical Properties
|
M.Wt
|
303.29
|
|
Formula
|
C14H9NO5S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(5,6-dihydroxybenzo[d]thiazol-2-yl)(3,4-dihydroxyphenyl)methanone
|
References
1. Venkataramani P, et al. Cell Chem Biol. 2026 Jun 10:S2451-9456(26)00157-1.
Contact Us
sales@probechem.com
