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Chemical Structure : Danuglipron
CAS No.: 2230198-02-2
Catalog No.: PC-72210Not For Human Use, Lab Use Only.
Danuglipron (PF-06882961) is a potent, selective, non-peptide and orally bioavailable agonist of glucagon-like peptide-1 receptor (GLP-1R) with cAMP production EC50 of 1.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $498 | In stock | |
| 250 mg | Get quote |
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Danuglipron (PF-06882961) is a potent, selective, non-peptide and orally bioavailable agonist of glucagon-like peptide-1 receptor (GLP-1R) with cAMP production EC50 of 1.1 nM.
Danuglipron (PF-06882961) is a full agonist (EC50 = 13 nM) in the CS cAMP assay.
Danuglipron (PF-06882961) is a partial agonist in recruiting βArr2 (EC50 = 490 nM; Emax = 36%), exhibits subtle bias for cAMP, relative to βArr1 recruitment.
Danuglipron (PF-06882961) shows Ki value of 360 nM using a competition binding assay.
Danuglipron (PF-06882961) does not activate the rodent GLP-1R.
Danuglipron (PF-06882961) demonstrated beneficial changes during a recently reported multiple-dose study in volunteers with T2DM.
| M.Wt | 555.61 | |
| Formula | C31H30FN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-((4-(6-((4-Cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylic acid |
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1. Zhang X, et al. Mol Cell. 2020 Nov 5;80(3):485-500.e7.
2. Choe HJ, et al. Endocrinol Metab (Seoul). 2021 Feb;36(1):22-29.
3. Saxena AR, et al. Nat Med. 2021 Jun;27(6):1079-1087.
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