Catalog No.: PC-72210Not For Human Use, Lab Use Only.
Danuglipron (PF-06882961) is a potent, selective, non-peptide and orally bioavailable agonist of glucagon-like peptide-1 receptor (GLP-1R) with cAMP production EC50 of 1.1 nM.
Danuglipron (PF-06882961) is a potent, selective, non-peptide and orally bioavailable agonist of glucagon-like peptide-1 receptor (GLP-1R) with cAMP production EC50 of 1.1 nM.
Danuglipron (PF-06882961) is a full agonist (EC50 = 13 nM) in the CS cAMP assay.
Danuglipron (PF-06882961) is a partial agonist in recruiting βArr2 (EC50 = 490 nM; Emax = 36%), exhibits subtle bias for cAMP, relative to βArr1 recruitment.
Danuglipron (PF-06882961) shows Ki value of 360 nM using a competition binding assay.
Danuglipron (PF-06882961) does not activate the rodent GLP-1R.
Danuglipron (PF-06882961) demonstrated beneficial changes during a recently reported multiple-dose study in volunteers with T2DM.
