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Chemical Structure : Didox
CAS No.: 69839-83-4
Catalog No.: PC-45630Not For Human Use, Lab Use Only.
Didox is a ribonucleotide reductase (RNR) inhibitor; overcomes Bcl-2 mediated radiation resistance in PC-3 cells, inhibits LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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Didox is a ribonucleotide reductase (RNR) inhibitor; overcomes Bcl-2 mediated radiation resistance in PC-3 cells, inhibits LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α.
Didox induces apoptosis and inhibits DNA repair in multiple myeloma cells by downregulation of bcl family proteins including bcl-2, bcl(xl), and XIAP.
Didox (150 mg/kg daily) significantly protects the cardiomyocyte membrane integrity and decreases the intra-cardiac oxidative stress induced by DOX treatment (15 mg/kg) in mice.
| M.Wt | 169.1348 | |
| Formula | C7H7NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N,3,4-trihydroxy- |
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1. Inayat MS, et al. Cancer Biol Ther. 2002 Sep-Oct;1(5):539-45.
2. Raje N, et al. Br J Haematol. 2006 Oct;135(1):52-61.
3. Al-Abd AM, et al. Eur J Pharmacol. 2013 Oct 15;718(1-3):361-9.
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