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Chemical Structure : EDP-305
CAS No.: 1933507-63-1
Catalog No.: PC-38044Not For Human Use, Lab Use Only.
EDP-305 (EDP305) is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 34 nM, shows antifibrotic effect.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
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| 100 mg | Get quote |
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EDP-305 (EDP305) is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 34 nM, shows antifibrotic effect.
EDP-305 displays antifibrotic effect in rodent models of cholestatic and fatty liver injury: bile duct ligation (BDL) in rats and choline‐deficient, L‐amino acid‐defined, high‐fat diet (CDAHFD) in mice.
EDP‐305 dose‐dependently decreases macrophage infiltration and proinflammatory cytokine gene expression.
EDP‐305 also dose‐dependently reduces interstitial fibrosis and kidney hydroxyproline levels.
EDP‐305 decreases TGF‐β1-induced YAP nuclear localization in human kidney 2 cells by increasing inhibitory YAP phosphorylation.
EDP‐305 reduces interstitial renal fibrosis in a mouse model of unilateral ureteral obstruction.
| M.Wt | 630.93 | |
| Formula | C36H58N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(1,1-Dimethylethyl)-N-[[[(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-24-norcholan-23-yl]amino]carbonyl]benzenesulfonamide |
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1. Erstad DJ, et al. Hepatol Commun. 2018 May 21;2(7):821-835.
2. Li S, et al. FASEB J. 2019 Jun;33(6):7103-7112.
3. An P, et al. Liver Int. 2020 Jul;40(7):1655-1669.
4. Ratziu V, et al. J Hepatol. 2022 Mar;76(3):506-517.
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