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Chemical Structure : ER-819762
Catalog No.: PC-61555Not For Human Use, Lab Use Only.
ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay.
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ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay.
ER-819762 inhibits EP4-stimulated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells.
ER-819762 exhibits no agonism or antagonism for the related PGE2 EP1, EP2 and EP3 receptors.
ER-819762 suppresses Th1 and Th17 cytokine production, suppresses disease in collagen- and GPI-induced arthritis in mice, and suppresses CFA-induced inflammatory pain in rats.
| M.Wt | 489.65 | |
| Formula | C30H39N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen Q, et al. Br J Pharmacol. 2010 May;160(2):292-310.
2. Jones VC, et al. Br J Pharmacol. 2016 Mar;173(6):992-1004.
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