Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ES936
CAS No.: 192820-78-3
Catalog No.: PC-60680Not For Human Use, Lab Use Only.
ES936 is a potent, specific mechanism-based human NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitor that demonstrates efficient inactivation of NQO1 at 100 nM in in cellular systems.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ES936 is a potent, specific mechanism-based human NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitor that demonstrates efficient inactivation of NQO1 at 100 nM in in cellular systems.
ES936 does not inhibit other cellular reductases, nor does it alter cellular levels of acid-soluble thiols.
ES936 abrogates the toxicity of streptonigrin, with greater effects seen in cell lines expressing higher levels of NQO1.
| M.Wt | 356.334 | |
| Formula | C18H16N2O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione |
|
1. Dehn DL, et al. Mol Pharmacol. 2003 Sep;64(3):714-20.
2. Winski SL, et al. Biochemistry. 2001 Dec 18;40(50):15135-42.
3. Anwar A, et al. J Biol Chem. 2003 Mar 21;278(12):10368-73.
4. Gustafson DL, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1079-86.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
