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Chemical Structure : ETG-5773
CAS No.: 23794-80-1
Catalog No.: PC-49269Not For Human Use, Lab Use Only.
ETG-5773 (ETG5773) is a selective, cross-species active, non-competitive, non-substrate-like inhibitor of NaCT (SLC13A5, INDY), reduces citrate uptake in cell lines expressing mouseor human NaCT with IC50 of 180 and 160 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $328 | In stock | |
| 25 mg | $528 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | Get quote |
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ETG-5773 (ETG5773) is a selective, cross-species active, non-competitive, non-substrate-like inhibitor of NaCT (SLC13A5, INDY), reduces citrate uptake in cell lines expressing mouseor human NaCT with IC50 of 180 and 160 nM, respectively.
ETG-5773 displays no activiity on the closely related human NaDC3 (SLC13A3) transporter at 20 uM.
ETG-5773 (15 mg/kg twice-daily, oral) ameliorates diet-induced obesity in DIO mice.
ETG-5773 attenuates hepatic steatosis and regulates lipogenesis-related genes, significantly downregulates Acly mRNA levels.
ETG-5773 is able to reduce liver fat and other features of metabolically associated fatty liver disease (MAFLD).
| M.Wt | 335.630 | |
| Formula | C11H8ClF6NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3,3,3-trifluoropropyl (3-chloro-5-(trifluoromethyl)phenyl)carbamate |
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1. Grit Zahn, et al. Metabolites. 2022 Aug 8;12(8):732.
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