Chemical Structure : Ebio2
CAS No.:
Ebio2
Catalog No.: PC-23868Not For Human Use, Lab Use Only.
Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV.
Ebio2 (10 nM) enhances KCNQ2 currents by an average factor of 7.4 ± 0.3 and considerably shifted the half-maximal activation voltage (V1/2) to a more hyperpolarized potential by 32.7 ± 1.2 mV, from −15.2 ± 1.6 mV to −47.8 ± 1.6 mV.
Ebio2 also shifts the KCNQ2 activation curve to a hyperpolarizing direction, with an EC50 value of 4.5 nM.
Ebio2 exhibits over 100 times greater potency in modulating the KCNQ2 channel than Ebio1 (Cat# PC-21613).
Ebio2 exhibits over 100-fold subtype selectivity compared to all other KCNQ channels.
Physicochemical Properties
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M.Wt
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335.35
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Formula
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C17H19F2N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(7-(difluoromethoxy)-1-(prop-2-yn-1-yl)-1H-indazol-3-yl)-3,3-dimethylbutanamide
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References
1. Li J, et al. Nat Chem Biol. 2025 Jan 15. doi: 10.1038/s41589-024-01834-8.
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