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Chemical Structure : Encorafenib
CAS No.: 1269440-17-6
Catalog No.: PC-49770Not For Human Use, Lab Use Only.
Encorafenib (NVP-LGX818, LGX818) a potent, selective BRAF inhibitor with IC50 of 0.35, 0.47, and 0.3 nM against BRAF V600E, wild-type BRAF and CRAF in vitro cell-free assays, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | $588 | In stock | |
| 250 mg | Get quote |
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Encorafenib (NVP-LGX818, LGX818) a potent, selective BRAF inhibitor with IC50 of 0.35, 0.47, and 0.3 nM against BRAF V600E, wild-type BRAF and CRAF in vitro cell-free assays, respectively.
Encorafenib (NVP-LGX818, LGX818) is able to bind to other kinases in vitro including JNK1, JNK2, JNK3, LIMK1, LIMK2, MEK4, and STK36 and significantly reduce ligand binding to these kinases at clinically achievable concentrations (<0.9 uM).
Encorafenib (NVP-LGX818, LGX818) inhibited the in vitro cell growth of tumor cell lines that express BRAF V600 E, D, and K mutations.
Encorafenib (NVP-LGX818, LGX818) induced tumor regressions associated with RAF/MEK/ERK pathway suppression in mice implanted with tumor cells expressing the BRAF V600E mutation.
| M.Wt | 540.01 | |
| Formula | C22H27ClFN7O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
methyl (S)-(1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate |
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1. Adelmann CH, et al. Oncotarget. 2016 May 24;7(21):30453-60.
2. Krepler C, et al. Clin Cancer Res. 2016 Apr 1;22(7):1592-602.
3. van Geel RMJM, et al. Cancer Discov. 2017 Jun;7(6):610-619.
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