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Chemical Structure : Extracellular vesicle enhancer 634
Catalog No.: PC-20657Not For Human Use, Lab Use Only.
Extracellular vesicle enhancer 634 (Compound 634) is a small molecule enhancer of extracellular vesicle (EV) release with immunostimulatory potency via induction of Ca2+ influx, which is mediated by store-operated Ca2+ entry (SOCE).
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Extracellular vesicle enhancer 634 (Compound 634) is a small molecule enhancer of extracellular vesicle (EV) release with immunostimulatory potency via induction of Ca2+ influx, which is mediated by store-operated Ca2+ entry (SOCE).
Compound 634 induced Ca2+ influx in primary mBMDCs, and the increase of intracellular Ca2+ was comparable to that of ION (1 μM).
Compound 634 (10 uM) enhanced EV release in mBMDCs.
Compound 634 enhanced costimulatory molecule expression on mBMDC, 634-treated mBMDCs also had increased CD86 and CD80 expression.
Compound 634 is a Ca2+ influx inducer mediated by SOCE, EVs isolated from 634-treated mBMDCs induced T cell proliferation in the presence of antigenic peptides.
| M.Wt | 397.48 | |
| Formula | C15H15N3O4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sako Y, et al. ACS Chem Biol. 2023 Apr 11. doi: 10.1021/acschembio.3c00134.
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