Chemical Structure : Extracellular vesicle enhancer 634
CAS No.:
882291-37-4
Extracellular vesicle enhancer 634
(Compound 634)
Catalog No.: PC-20657Not For Human Use, Lab Use Only.
Extracellular vesicle enhancer 634 (Compound 634) is a small molecule enhancer of extracellular vesicle (EV) release with immunostimulatory potency via induction of Ca2+ influx, which is mediated by store-operated Ca2+ entry (SOCE).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Extracellular vesicle enhancer 634 (Compound 634) is a small molecule enhancer of extracellular vesicle (EV) release with immunostimulatory potency via induction of Ca2+ influx, which is mediated by store-operated Ca2+ entry (SOCE).
Compound 634 induced Ca2+ influx in primary mBMDCs, and the increase of intracellular Ca2+ was comparable to that of ION (1 μM).
Compound 634 (10 uM) enhanced EV release in mBMDCs.
Compound 634 enhanced costimulatory molecule expression on mBMDC, 634-treated mBMDCs also had increased CD86 and CD80 expression.
Compound 634 is a Ca2+ influx inducer mediated by SOCE, EVs isolated from 634-treated mBMDCs induced T cell proliferation in the presence of antigenic peptides.
Physicochemical Properties
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M.Wt
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397.48
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Formula
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C15H15N3O4S3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)SC(C)=C1C)OCC
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References
1. Sako Y, et al. ACS Chem Biol. 2023 Apr 11. doi: 10.1021/acschembio.3c00134.
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