Chemical Structure : F2F-202
CAS No.:
F2F-202
Catalog No.: PC-26831Not For Human Use, Lab Use Only.
F2F-202 is a a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.1 nM, shows great selectivity over HDAC1 and selected as a representative of nuclear HDACs (422-fold), shows synergistic activity in combination with the azole antifungal voriconazole.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
F2F-202 is a a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.1 nM, shows great selectivity over HDAC1 and selected as a representative of nuclear HDACs (422-fold), shows synergistic activity in combination with the azole antifungal voriconazole.
F2F-202 shows synergistic activity in combination with the azole antifungal voriconazole (VRC) through the modulation of fungal histone deacetylase Hda1.
F2F-202 shows growth inhibition against the azole-resistant C. albicans ATCC 10231 strain in combination with VRC, combined with a significant reduction of yeast-to-hyphae morphological transition.
Synergistic combination F2F-202/VRC affects the expression of key genes regulated by Hda1 activity and involved in morphogenesis, namely, Nrg1, Als1, and Hpw1.
Synergistic combination F2F-202/VRC counteracts the VRC-induced upregulation of Erg11, a gene involved in C. albicans azole resistance.
Physicochemical Properties
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M.Wt
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643.79
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Formula
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C36H45N5O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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tert-butyl ((2S,3R)-3-hydroxy-4-(3-(4-(hydroxycarbamoyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-1-phenylbutan-2-yl)carbamate
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References
1. Barone S, et al. ACS Infect Dis. 2026 May 22. doi: 10.1021/acsinfecdis.6c00195.
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