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Chemical Structure : FABP4/5 inhibitor compound 2
CAS No.: 1227413-92-4
Catalog No.: PC-38572Not For Human Use, Lab Use Only.
FABP4/5 inhibitor compound 2 is a potent dual FABP4 and FABP5 inhibitor with Kd of 0.01 and 0.52 uM, respectively, reduces isoproterenol-stimulated lipolysis in mouse 3T3-L1 adipocytes with IC50 of 22 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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FABP4/5 inhibitor compound 2 is a potent dual FABP4 and FABP5 inhibitor with Kd of 0.01 and 0.52 uM, respectively, reduces isoproterenol-stimulated lipolysis in mouse 3T3-L1 adipocytes with IC50 of 22 uM.
FABP4/5 inhibitor compound 2 inhibited basal or isoproterenol-stimulated lipolysis in 3T3-L1 and primary human adipocytes.
FABP4/5 inhibitor compound 2 inhibited basal and LPS-stimulated MCP-1 release from THP-1 cells and primary human macrophages.
FABP4/5 inhibitor compound 2 ameliorated dyslipidemia but not insulin resistance in DIO mice.
| M.Wt | 366.805 | |
| Formula | C19H15ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-((3-chloro-2-methylphenoxy)methyl)-2-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(1H)-one |
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1. Hong Lan, et al. J Lipid Res. 2011 Apr;52(4):646-56.
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