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Chemical Structure : FAK degrader F2
Catalog No.: PC-22493Not For Human Use, Lab Use Only.
FAK PROTAC F2 is a potent, selective FAK CRBN-recruiting PROTAC degrader based on the FAK inhibitor Ifebemtinib (IN10018) with DC50 of 27.72 nM and 60.10 nM for total FAK and phosphorylated FAK in MDA-MB-231 cells.
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FAK PROTAC F2 is a potent, selective FAK CRBN-recruiting PROTAC degrader based on the FAK inhibitor Ifebemtinib (IN10018) with DC50 of 27.72 nM and 60.10 nM for total FAK and phosphorylated FAK in MDA-MB-231 cells.
FAK PROTAC F2 exhibits potent inhibitory activities against 4T1, MDA-MB-231, MDA-MB-468 and MDA-MB-435 cells with IC50 values of 0.73, 1.09, 5.84 and 3.05 μM, respectively.
FAK PROTAC F2 also remarkably reversed the multidrug resistance (MDR) in HCT8/T, A549/T and MCF-7/ADR cells.
FAK PROTAC F2 exerts anti-tumor effects by inhibiting AKT and ERK signaling pathways and affecting EMT (epithelial-mesenchymal transition).
FAK PROTAC F2 reverses the resistance of multidrug-resistant tumor cells to chemotherapy drugs in vitro and in vivo.
| M.Wt | 926.93 | |
| Formula | C47H46F4N8O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu MS, et al. Acta Pharmacol Sin. 2024 Jun 6. doi: 10.1038/s41401-024-01312-w.
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