FC162 | DYRK1A inhibitor | Probechem Biochemicals

Chemical Structure : FC162

FC162 (FC 162)

Catalog No.: PC-21495Not For Human Use, Lab Use Only.

FC162 is a potent inhibitor of DYRK1A with IC50 of 11, 18, and 68 nM, against DYRK1A, CLK1, and GSK3, respectively.

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Biological Activity

FC162 is a potent inhibitor of DYRK1A with IC50 of 11, 18, and 68 nM, against DYRK1A, CLK1, and GSK3, respectively.
FC162 (0-30 uM) dose-dependently inhibits Tau phosphorylation at Thr21 in SH-SY5Y cells expressing Tau.
FC162 reduces cyclin D3 phosphorylation and impairs the entry to quiescent state.
FC162 treatment phenocopies the effect of Dyrk1a genetic deletion in pre-B cells.

Physicochemical Properties

M.Wt	320.37
Formula	C17H12N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-cyclopropyl-2(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one

References

1. Corinne Fruit, et al. Pharmaceuticals (Basel). 2019 Dec 17;12(4):185.

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FC162 (FC 162)

Biological Activity

Physicochemical Properties

References

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