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FLC-8

Chemical Structure : FLC-8

CAS No.: 3100242-36-9

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FLC-8

Catalog No.: PC-26471Not For Human Use, Lab Use Only.

FLC-8 is a potent, selective and covalent FLT3 inhibitor with IC50 of 10.2 nM, 11.6 nM and 24.1 nM for FLT3-WT, FLT3 G697R and FLT3 N676D respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FLC-8 is a potent, selective and covalent FLT3 inhibitor with IC50 of 10.2 nM, 11.6 nM and 24.1 nM for FLT3-WT, FLT3 G697R and FLT3 N676D respectively.
FLC-8 covalently target Cys807, a nucleophilic residue within the FLT3 kinase domain.
FLC-8 suppressed FLT3-mediated STAT5, AKT, and ERK signaling and induced apoptosis in AML cells while maintaining low-nanomolar potency over 72 h.
FLC-8 inhibited MV4-11 xenograft growth (TGI: 136–178% at 10–50 mg/kg) without overt toxicity.

Physicochemical Properties

M.Wt 496.45
Formula C24H19F3N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(3-(4-(3-Amino-6-methylisoxazolo[5,4-b]pyridin-4-yl)phenyl)ureido)-2-(trifluoromethyl)phenyl)acrylamide

References

1. Wang ZX, et al. J Med Chem. 2026 Apr 3. doi: 10.1021/acs.jmedchem.6c00511.

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