Catalog No.: PC-38520Not For Human Use, Lab Use Only.
FLTX1 is a fluorescent tamoxifen derivative, colocalizes with estrogen receptor α (ERα), can specifically label intracellular Tamoxifen-binding sites (estrogen receptors).
FLTX1 is a fluorescent tamoxifen derivative, colocalizes with estrogen receptor α (ERα), can specifically label intracellular Tamoxifen-binding sites (estrogen receptors).
FLTX1 exhibits similar affinity for ER than tamoxifen.
FLTX1 exhibited antiestrogenic activity comparable to tamoxifen in MCF7 and T47D cells transfected with 3xERE-luciferase reporter.
FLTX1 lacked the strong agonistic effect of tamoxifen on ERα-dependent transcriptional activity.
FLTX1 is not only a suitable probe for studies on the molecular pharmacology of tamoxifen, but also a potential therapeutic substitute to tamoxifen.
