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Chemical Structure : FLTX1
CAS No.: 1481401-71-1
Catalog No.: PC-38520Not For Human Use, Lab Use Only.
FLTX1 is a fluorescent tamoxifen derivative, colocalizes with estrogen receptor α (ERα), can specifically label intracellular Tamoxifen-binding sites (estrogen receptors).
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FLTX1 is a fluorescent tamoxifen derivative, colocalizes with estrogen receptor α (ERα), can specifically label intracellular Tamoxifen-binding sites (estrogen receptors).
FLTX1 exhibits similar affinity for ER than tamoxifen.
FLTX1 exhibited antiestrogenic activity comparable to tamoxifen in MCF7 and T47D cells transfected with 3xERE-luciferase reporter.
FLTX1 lacked the strong agonistic effect of tamoxifen on ERα-dependent transcriptional activity.
FLTX1 is not only a suitable probe for studies on the molecular pharmacology of tamoxifen, but also a potential therapeutic substitute to tamoxifen.
| M.Wt | 520.58 | |
| Formula | C31H28N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]ethyl]-N-methyl-7-nitro-2,1,3-benzoxadiazol-4-amine |
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1. Marrero-Alonso J, et al. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt B):898-910.
2. Morales A, et al. Methods Mol Biol. 2016;1366:163-173.
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