Chemical Structure : FM101
CAS No.:
945457-84-1
FM101
(FM-101, LJ-2698)
Catalog No.: PC-23909Not For Human Use, Lab Use Only.
FM101 is a highly potent and selective antagonist of A3 adenosine receptor (A3AR), selectively binds to human A3AR with Ki of 1.44 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FM101 is a highly potent and selective antagonist of A3 adenosine receptor (A3AR), selectively binds to human A3AR with Ki of 1.44 nM.
FM101 causes cAMP inhibition through Gα protein-dependent signaling with EC50 of 104 nM.
FM101 is a potent antagonist of β-arrestin dependent signaling with IC50 of 44 nM.
FM101 induces β-arrestin2-mediated A3AR degradation, leading to mitochondrial dysfunction-mediated necroptosis in Kupffer cells (KCs).
FM101 alleviates MASLD by inducing mitochondrial dysfunction and subsequent necroptosis in monocyte-derived KCs (MoKCs).
Physicochemical Properties
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M.Wt
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412.29
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Formula
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C16H15Cl2N5O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R,3R,4S)-2-[2-chloro-6-(3-chlorobenzylamino)-9H purine-9-yl]-tetrahydrothiophene-3,4-diol
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References
1. Park JS, et al. Metabolism. 2024 Dec 26;164:156114.
2. Chong-Woo Park, et al. EXCLI J. 2020 Feb 12:19:187-200.
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