Chemical Structure : FMP-201300
CAS No.:
312922-93-3
FMP-201300
(FMP201300)
Catalog No.: PC-21232Not For Human Use, Lab Use Only.
FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively.
FMP-201300 binds to an allosteric pocket adjacent to the ATP binding site.
FMP-201300 shows no known inhibitory activities against other biological targets and does not display any recognized PAINS motifs.
FMP-201300 is neither redox-active, nor cytotoxic, against HEK293 or HepG2 cell lines at a concentration of 10 µM.
Physicochemical Properties
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M.Wt
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572.49
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Formula
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C31H16N4O8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4-(6-(5-carboxy-1,3-dioxoisoindolin-2-yl)-1H-benzo[d]imidazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid
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References
1. Aguirre T, et al. Elife. 2023 Oct 16;12:RP88982.
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