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FMP-201300

Chemical Structure : FMP-201300

CAS No.: 312922-93-3

FMP-201300 (FMP201300)

Catalog No.: PC-21232Not For Human Use, Lab Use Only.

FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively.
FMP-201300 binds to an allosteric pocket adjacent to the ATP binding site.
FMP-201300 shows no known inhibitory activities against other biological targets and does not display any recognized PAINS motifs.
FMP-201300 is neither redox-active, nor cytotoxic, against HEK293 or HepG2 cell lines at a concentration of 10 µM.

Physicochemical Properties

M.Wt 572.49
Formula C31H16N4O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4-(6-(5-carboxy-1,3-dioxoisoindolin-2-yl)-1H-benzo[d]imidazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid

References

1. Aguirre T, et al. Elife. 2023 Oct 16;12:RP88982.

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