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Chemical Structure : Fenebrutinib
CAS No.: 1434048-34-6
Catalog No.: PC-45739Not For Human Use, Lab Use Only.
Fenebrutinib (RG-7845, GDC-0853) is an orally bioavailable, selective, non-covalent and reversible BTK inhibitor with IC50 of 2-9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Fenebrutinib (RG-7845, GDC-0853) is an orally bioavailable, selective, non-covalent and reversible BTK inhibitor with IC50 of 2-9 nM.
Fenebrutinib (RG-7845, GDC-0853) has demonstrated efficacy in pre-clinical autoimmune disease models and is being developed for the treatment of rheumatoid arthritis and lupus, with future development for other autoimmune indications.
| M.Wt | 664.7964 | |
| Formula | C37H44N8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 23 mg/mL |
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| Chemical Name/SMILES |
2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, 2-[1,6-dihydro-3'-(hydroxymethyl)-1-methyl-5-[[5-[(2S)-2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-6-oxo[3,4'-bipyridin]-2'-yl]-3,4,7,8-tetrahydro-7,7-dimethyl- |
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1. Erickson RI, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):226-238.
2. Katsumoto, T. 2016 ACR/ARHP Annual Meeting (2016).
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