Foretinib |CAS:849217-64-7 Probechem Biochemicals

Chemical Structure : Foretinib

CAS No.: 849217-64-7

Foretinib (XL880;GSK1363089;GSK089;EXEL-2880)

Catalog No.: PC-42535Not For Human Use, Lab Use Only.

Foretinib (XL880, GSK1363089, GSK089, EXEL-2880) is a potent, multikinase inhibitor that inhibits c-Met and VEGFR, also KIT, Flt-3, PDGFRβ, and Tie-2.

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$198	In stock
50 mg	$298	In stock
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Foretinib (XL880, GSK1363089, GSK089, EXEL-2880) is a potent, multikinase inhibitor that inhibits c-Met and VEGFR, also inhibits KIT, Flt-3, PDGFRβ, and Tie-2.
Foretinib inhibits HGFR family tyrosine kinases with IC50 of 0.4 nM for Met and 3 nM for Ron, also inhibits KDR, Flt-1, and Flt-4 with IC50 of 0.9, 6.8, and 2.8 nM, respectively.
Foretinib exhibits modest activity against FGFR1 and EGFR, no activity against 50 serine/threonine kinases, including CDKs and PKC isoforms.
Foretinib inhibits cellular HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation and prevents both HGF-induced responses of tumor cells and HGF/VEGF-induced responses of endothelial cells.
Foretinib exhibits significant inhibition of tumor burden in animal model of lung metastasis.

Physicochemical Properties

M.Wt	632.6537
Formula	C34H34F2N4O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 38 mg/mL
Chemical Name/SMILES	1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-

References

1. Qian F, et al. Cancer Res. 2009 Oct 15;69(20):8009-16.

2. Liu L, et al. Cancer Res. 2009 Sep 1;69(17):6871-8.

3. Eder JP, et al. Clin Cancer Res. 2010 Jul 1;16(13):3507-16.

Foretinib (XL880;GSK1363089;GSK089;EXEL-2880)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.