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Chemical Structure : GAT2711
Catalog No.: PC-22294Not For Human Use, Lab Use Only.
GAT2711 is a potent, selective full agonist of α9 nAChR with EC50 of 230 nM, 340-fold selective over α7 nAChR.
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GAT2711 is a potent, selective full agonist of α9 nAChR with EC50 of 230 nM, 340-fold selective over α7 nAChR.
GAT2711 significantly and dose-dependently inhibited (IC50= 0.5 μM) the BzATP-induced release of IL-1β in human monocytic THP-1 cells.
GAT2711 (10 mg/kg body weight) fully attenuated inflammatory pain in an α7 nAChR-independent manner in CFA-induced chronic inflammatory pain model.
| M.Wt | 466.37 | |
| Formula | C20H27IN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Andleeb H, et al. J Med Chem. 2024 May 15. doi: 10.1021/acs.jmedchem.3c02429.
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