GAT2711 | α9 nAChR agonist | Probechem Biochemicals

Chemical Structure : GAT2711

GAT2711 (GAT-2711)

Catalog No.: PC-22294Not For Human Use, Lab Use Only.

GAT2711 is a potent, selective full agonist of α9 nAChR with EC50 of 230 nM, 340-fold selective over α7 nAChR.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

GAT2711 is a potent, selective full agonist of α9 nAChR with EC50 of 230 nM, 340-fold selective over α7 nAChR.
GAT2711 significantly and dose-dependently inhibited (IC50= 0.5 μM) the BzATP-induced release of IL-1β in human monocytic THP-1 cells.
GAT2711 (10 mg/kg body weight) fully attenuated inflammatory pain in an α7 nAChR-independent manner in CFA-induced chronic inflammatory pain model.

Physicochemical Properties

M.Wt	466.37
Formula	C20H27IN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Ethyl-1-methyl-4-(4-(6-methylpicolinamido)phenyl)piperazin-1-ium Iodide

References

1. Andleeb H, et al. J Med Chem. 2024 May 15. doi: 10.1021/acs.jmedchem.3c02429.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

GAT2711 (GAT-2711)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.